Alabama vs.Southern Mississippi

 
  Date: 9/16/2000  
  Score: 0-21  
  Alabama vs. Southern Mississippi For the first time since 1997, the Tide was shutout and lost to the Golden Eagles by a score of 21-0. Even though the score indicates otherwise, the defense was solid in only allowing 210 yards of total offense and a single touchdown to Southern. Alabama turned the ball over four times, and two of those turnovers were returned for touchdowns by the Eagles defense. The 2000 squad would finish the season with a record of 3-8 in Mike Dubose's final season as head coach of the Tide.